Both are West Bank settlers averse to Palestinians' self-rule - let alone their hopes of statehood.
Netanyahu's previous 15 years as premier saw him feathering the nests of the hawks in his cabinet - or clipping their wings - as he deemed necessary.
But that may have to wait, as Ben-Gvir's portfolio does not grant major powers in the West Bank, which is under the overall control of the military.
Arguably, Ben-Gvir, 46, and Smotrich, 42, can afford to shelve some of their agendas for this round with Netanyahu, 73.
Smotrich's advocacy of Jewish claims on the West Bank is informed by a doctrinaire faith in Bible prophesy.